Pharmacokinetics of alkylresorcinol metabolites in human urine
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of alkylresorcinol metabolites in human urine.
Wholegrain cereals are reported to promote beneficial health effects. Wholegrain wheat and rye are almost exclusive sources of alkylresorcinols, and intact alkylresorcinols together with their plasma and urinary metabolites, 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), have been proposed as biomarkers of the intake of these foods in humans. The pharmaco...
متن کاملIdentification and pharmacokinetics of novel alkylresorcinol metabolites in human urine, new candidate biomarkers for whole-grain wheat and rye intake.
Biomarkers of dietary intake are prominent tools in nutritional research. The alkylresorcinol metabolites 3,5-dihydroxybenzoic acid (3,5-DHBA) and 3-(3,5-dihydroxyphenyl)propanoic acid (3,5-DHPPA) have been proposed as exposure biomarkers of whole-grain (WG) wheat and rye intake. However, the profile of alkylresorcinol metabolites is not fully understood. The aim of this study was to investigat...
متن کاملQuantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection.
BACKGROUND Whole-grain rye and wheat cereals contain high amounts of alkylresorcinols (ARs), phenolic lipids. ARs can be quantified in plasma. Two recently identified urinary AR metabolites, 3,5-dihydroxyphenylbenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), may be useful as biomarkers of intake of whole-grain rye and wheat. METHODS We evaluated 4 pretreatment protoco...
متن کاملPlasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake.
BACKGROUND Alkylresorcinols are phenolic compounds that are present almost exclusively in rye and wheat fiber. Alkylresorcinols are absorbed and thereafter metabolized to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have been detected in human urine and plasma. OBJECTIVE The objective was to determine the plasma pharmacokinetics of DHBA and DHPP...
متن کاملProfile of volatile metabolites in human urine.
Volatile constituents of 30 urines from 10 adults have been studied by gas chromatography, and two also by mass spectrometry. The sample was prepared by extracting urine with ethyl ether, distilling the extract at low temperature under reduced pressure, and concentrating the distillate to a few microliters. High-efficiency capillary columns, 150 m X 0.5 mm i.d., provide the resolution necessary...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2011
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114511001383